PRIMARY MYELOFIBROSIS
نویسندگان
چکیده
منابع مشابه
Primary myelofibrosis: current therapeutic options
Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to t...
متن کاملTreatment considerations for primary myelofibrosis.
j u l y/ a u g u s t 2 0 1 0 , v o l . 6 8 , n o 7 / 8 Primary myelofibrosis (PMF) belongs to the group of Philadelphia chromosome negative (Ph) chronic myeloproliferative neoplasms caused by a clonal stem cell disorder presenting with myeloproliferation and fibrosis. The clinical presentation is characterised by anaemia, marked hepatosplenomegaly, leuko-erythroblastosis, constitutional symptom...
متن کاملBiology and treatment of primary myelofibrosis.
Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder associated with an average survival of less than 5 years. Therapy for PMF has used chemotherapeutic agents, immunomodulatory drugs, or biological-response modifiers that have not always been directed at the biological processes that underlie the origins of PMF. Such strategies are palliative and have an uncertain effect on sur...
متن کاملThalidomide and lenalidomide in primary myelofibrosis.
Primary myelofibrosis is a clonal haematopoietic stem cell disease, characterised by marrow stromal fibrosis, extramedullary haematopoiesis, splenomegaly, hepatomegaly and progressive cytopenia. Therapeutic options once cytopenia has developed are limited to supportive care, such as erythrocyte transfusions and growth factors. The aetiology has become more clear, especially since JAK-2 mutation...
متن کاملProgression of primary myelofibrosis to polycythemia vera
RATIONALE This case report describes the progression of primary myelofibrosis (PMF) to polycythemia vera (PV), and discuss its potential mechanisms. PATIENT CONCERNS The patient was admitted because of abdominal discomfort and enlarged spleen for 19 months. DIAGNOSIS A case of PMF progressed to PV was retrospectively analyzed. There were 19 months between the diagnosis of PMF and PV. The JA...
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ژورنال
عنوان ژورنال: INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
سال: 2019
ISSN: 2477-4685,0854-4263
DOI: 10.24293/ijcpml.v25i1.1518